Paulina Skupin-Mrugalska is an Associate Professor at Poznan University of Medical Sciences, Poland. In 2022, she was awarded a scholarship for outstanding young scientists by the Minister of Education and Science, one of the most prestigious recognitions for young scientists in Poland.
She obtained her M.Sc. (2009), Ph.D. (2014) and habilitation (2022) in Pharmaceutical Sciences at Poznan University of Medical Sciences. In the meantime, she worked as a junior pharmacist at the oncology unit of the hospital pharmacy Lord's Transfiguration Clinical Hospital in Poznan, Poland. In 2010 and 2012, Paulina joined a research group led by Prof. Nejat Düzgünes, University of Pacific, Arthur A. Dugoni School of Dentistry (San Francisco, CA, USA) as a young visiting researcher, where she started her research in the field of liposomal technology. In 2013, Paulina was appointed a member of the Faculty of Pharmacy, PUMS (Poland). She was a visiting researcher at the University of Southern Denmark, Professor Martin Brandl's group (2018) and a post-doctoral fellow at Professor Tamara Minko's lab at Rutgers University, USA (2019/2020 and 2023). In 2024, she initiated and established the Controlled Release Society Poland Local Chapter and was appointed the President of the CRS Poland Local Chapter. She is a member of the Controlled Release Society and Phospholipid Research Center. She managed several research projects financed by the National Science Centre, the National Centre for Research and Development, and the Phospholipid Research Center. Paulina was a supervisor of several Master's students, auxiliary supervisor of one PhD (completed), and now supervises three PhD candidates.
Paulina is an enthusiastic professional searching for academia and industry opportunities, collaboration, and common initiatives. Her recent research focus involves enabling formulations for oral and parenteral delivery, phospholipid-based drug delivery, theranostic liposomes, RNA delivery technologies based on Lipid Nanoparticles (LNP) and their biological interfaces.
Hirsch index: 24
IF: 248.419
MNISW: 4975
Citations: 1706
Łukasz Sobotta, Marcin Wierzchowski, Nejat Düzgünes, Krystyna Konopka, Jan Balzarini, Tomasz Gośliński, Jadwiga Mielcarek. Alkoxyphthalocyanines and potential application for photodynamic therapy. XI Meždunarodnaâ škola-konferenciâ molodyh učenyh po himii porfirinov i ih analogov (200 let otkrytiû hlorofilla). Tezisy. Ivanovo, 19-23 sentâbrâ 2017
Team Award of Polish Minister of Health for scientific achievements in 2024
Best review of Nanomaterials in 2022
Team Award of University of Medical Sciences Rector in 2013,2014, 2016, 2017, 2018, 2020, 2021, 2022
Individual Award of University of Medical Sciences Rector in 2015 and 2019
The best presentation award on XI International School-Conference of Young Scientists on Chemistry of Porphyrins and their Analogues, 2017, Ivanovo, Russian Federation
Book chapter:
Głowacka-Sobotta A., Ziental D., Sobotta L. Porphyrinoids used for photodynamic inactivation against bacteria. W: Applications of porphyrinoids as functional materials. Royal Society of Chemistry, 2021, s. 352-404
10/2023 to current - Adiunkt / Assistant Professor
Department of Inorganic and Analytical Chemistry at the Faculty of Pharmacy of PUMS – Poznań
10/2019 to 10/2023 - Assistant Tutor (half-time job)
Department of Inorganic and Analytical Chemistry at the Faculty of Pharmacy of PUMS – Poznań
10/2018 to current
Pharmacist at Community Pharmacy
03/2023
Ph.D.: Pharmacy
Poznan University of Medical Sciences - Poznań
03/2019
Master's Degree: Pharmacy
Poznan University of Medical Sciences - Poznan
Internship - University of Turin prof. Loredana Serpe group - (03-04.2024)
Internship - Universidad Autonoma de Madrid - prof. Tomas Torres Group (01-06.2018)
Internship - Vitebsk State Medical University, Belarus (09.2016)
10th Polish-German Symposium (Dusseldorf; Niemcy) - 2023
„Can there be synergy between two different sensitizers in combined photosonodynamic treatment of drug-resistant bacteria?”
18th International Photodynamic Association World Congress (Tapere; Finlandia) - Gold Session Award - 2023
“Combination of photodynamic therapy with antibiotic therapy - future or misalliance?”
29th Young Research Fellows Meeting (Nantes, Francja) - 2022
“Synergy of antibiotic therapy and PACT with the use of new chlorin derivatives as photosensitizers”
9th Polish-German Symposium (Krakow; Niemcy) - 2017
“Development of the photosensitizer from synthesis to the antimicrobial activity” (awarded)
The city's award for young outstanding scientists from the Poznań academic community (2023)
Recipient of Outstanding Reviewer Award MDPI, 2022; for "Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine"
Individual Award of the Rector of Poznan University of Medical Sciences for scientific achievements (2023)
Team Award of the Rector of Poznan University of Medical Sciences for scientific achievements (2021 and 2022)
Heiniel Foundation Scholarship
First Team Grant (FNP) - Principal investigator
"Development of biocompatible porphyrinoid derivatives as light-activated plant protection agents"
Miniatura-7 Grant (NCN) - Project leader
"Liposomal formulations of violacein and deoxyviolacein in sonodynamic and photodynamic therapy"
Other significant achievements
Organizations and association
Department of Inorganic and Analytical Chemistry
Poznan University of Medical Sciences
A graduate of the University of Opole and Wrocław University of Science and Technology (major in biotechnology), she obtained her doctorate at the Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences in the field of biology, specializing in immunology. She is interested in tissue engineering and neuroimmunology, especially in the context of brain degeneration and regeneration processes. She is currently working on a project on targeted drug delivery systems based on lipid vesicles and nanoparticle-molecular corona interactions with cells.
A committed PhD student specializing in the preparation of amorphous solid dispersions and lipid nanoparticles. He has experience in biopharmaceutical evaluation in cell-free and animal-free models acquired during internships abroad.
2022 - ongoing
PhD student
Poznan University of Medical Sciences - Poznań
2015 - 2021
Master's Degree: Pharmacy
Poznan University of Medical Sciences - Poznan
10.2023 - 02.2024
University of Southern Denmark, scientific internship, Prof. Brandl’s lab
03.2021 - 09.2021
University of Southern Denmark, scientific internship, Prof. Brandl’s lab
01.2020 - 06.2020
University of Southern Denmark, Erasmus+, Prof. Brandl’s lab
2022 - ongoing
PRELUDIUM-20, „RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized therapyą”, principal investigator
2021 - ongoing
Lider XI, „New phospholipid matrices for pharmaceutical use”, investigator
2021 - 2024
Phospholipid Research Centre „Phospholipids as excipients in amorphous Solid Dispersions: an attempt to establish hot-melt-extrusion for oral formulation of poorly soluble drugs”, main investigator
PhD student in the Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poland
MSc in Pharmaceutical Engineering, Poznan University of Technology/Poznan University of Medical Sciences, Poland
My research focuses on developing nanoparticle-based drug delivery systems and biocorona studies. Biocorona is a coating on the surface of nanoparticles upon exposure to biological fluid. Biocorona composition involves proteins, sugars, fats, antibodies, and other ingredients. Biocorona-coated nanoparticles present different properties compared to unmodified NPs. The additional biolayer on the nanoparticle surface affects its size, surface charge, stability, and biological interactions. Research on the nanoparticle biocorona allows us to understand its role in the delivery of drug substances via nanoparticles.
Aleksandra Pawska graduated from the Karol Marcinkowski Medical University in Poznan with a master's in Forensic and Forensic Analytics in 2022-2024. She is a fifth-year pharmacy student and a doctoral student in the Department of Inorganic and Analytical Chemistry. Previously, she earned a bachelor's degree in Forensic and Forensic Analytics from the same university in 2019-2022. Aleksandra completed an internship in the Quality Control department of the pharmaceutical and chemical company Synteza sp. z o.o. in Poznan. She has presented numerous papers during her scientific career, including at the 24th International Congress Of Young Medical Scientists in Poznan in May 2024 and the 26th JCF Spring Symposium in Ulm, Germany in March 2024. She has also participated in conferences as a listener, including the International Conference on Chemical and Behavioral Addictions in Poznan, Poland in March 2023.
She has received numerous awards and honors for her scientific and social achievements, including a scholarship from the JM Rector of the Karol Marcinkowski Medical University in Poznan for the best students in 2021-2024 and a medal from the JM Rector for achievements in science and social work in 2022 and 2024. She also took second place for her presentation at the 23rd International Congress Of Young Medical Scientists in Poznan in 2022.
In her student career, Alexandra has been an active member of student scientific societies, serving, among others, as publication group coordinator of the SKN of Clinical Pharmacy since 2022, and as president and founder of the SKN of Chemistry of Synthetic Compounds in Photodynamic Therapy since 2019. She has also authored and co-authored numerous grant projects.
In the course of her scientific career, Alexandra has developed new pathways for the synthesis of metallocomplexes of aza-dipiromethene and aza-BODIPY compounds and carried out their characterization and analysis of their spectral properties, which is one of her most important scientific achievements. Currently, her research team is working on the synthesis and characterization of photosensitizers that are chlorite and porphyrin derivatives used in PACT (Photodynamic Antimicrobial Chemotherapy).
Education:
Employment:
Presentations given:
Training of young Staff in Students’ Research Group
PhD student in Department of Inorganic and Analytical Chemistry, PUMS
MPharm, Poznan University of Medical Sciences
I am working on novel oral phospholipid-based amorphous solid dispersions to enhance solubility and bioavailability of BCS type 2/4 drugs. In my research I'm also interested in preformulation studies, high-throughput screening tests, application of phospholipids in oral formulations and hot-melt extrusion.
PhD student and a fifth-year pharmacy student, is conducting his research in the Department of Inorganic and Analytical Chemistry. His dissertation is titled "Influence of Photosensitizers' Structure on Their Photochemical and Biological Activity." His scientific interests primarily focus on the development of photodynamic and sonodynamic therapies and their practical applications in the treatment of drug-resistant infections and cancer therapy. Additionally, he is involved in areas related to controlled drug delivery, nanotechnology, and the synthesis of macrocyclic compounds.
A third-year pharmacy student actively involved in scientific research. For over two years, he has been a leader of the Scientific Club "SKN Badań i Rozwoju API" at the Department of Inorganic and Analytical Chemistry, where he studies the activity and stability of photosensitizers. This year, he joined a grant project aimed at investigating porphyrinoid derivatives as potential plant protection agents against bacteria.
He has presented his scientific findings at several conferences, including: